Can I run it?

Can I run gemma 4 12b it on AMD Ryzen AI Max+ 395?

Runs great

Runs great fully in unified memory on your AMD Ryzen AI Max+ 395 at BF16, 8K context, about 5.2–7.1 tok/s. Weights 22.2 GB plus 0.81 GB of KV cache — 23.5 GB of 48.0 GB usable. Up to 256K context still fits.

Best quantBF16
Working context8K
Max that fits256K
Speed5.2–7.1 tok/sEstimate from memory bandwidth, not a benchmark. Method.
Weights22.2 GB
KV cache0.81 GB
Total23.5 GB
Usable48.0 GB

gemma 4 12b it details · AMD Ryzen AI Max+ 395 page · How this estimate is made

Run commands

llama.cpp
llama-server -hf unsloth/gemma-4-12b-it-GGUF:BF16 -c 8192 -ngl 48
Ollama
ollama run gemma
LM Studio
lms get unsloth/gemma-4-12b-it-GGUF
# Then load quant BF16

Assumptions

Larger models that also fit

Updated 2026-10-24. Profile on this page is the device default.